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Universal Integrated Diagnostic Sample Preparation for Rapid Quantitative and Qualitative Nucleic Acid Analysis. 3D1.19P, Transducers 01 / Eurosensors XV, June 10-14, 2001, Munich. Abstract
We are going to describe a versatile diagnostic sample preparation microsystem. The key element from which a variety of liquid and suspension handling functions can be implemented is the thermopneumatically actuated silicone valve. As compared to others we could reduce the thickness of the silicone membranes by a factor of ten down to 3 um which allows us to operate them in narrow channels of 20 to 50 um and at high density. They can partly and completely close these channels with a depth of 7 to 20 um at any time. this posiibility of fluid handling is in contrast to other cell manipulation techniques like electrostatic, light trap and electrophoresis. Especially pumps are easily added at no extra costs. These pumps are bi-directional and have no dead volume. Thus cleaning is easily possible in the completely open channels.
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R. Buser, D. Büchel, D. Baechi, P. Day: